Highlighted Publications

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​Glutamate neurons in the pedunculopontine tegmental nucleus control arousal state and motor behavior in mice

Authors: Brittany J Dugan, Hanhee Lee, John Peever
Journal: Sleep, 46:zsac322, 2023
​Read the paper here

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​Immortal orexin cell transplants restore motor-arousal synchrony during cataplexy

Authors: Sara K Pintwala, Jimmy J Fraigne, Denise D Belsham, John Peever
Journal: Current Biology, 33: 1550-1564, 2023
​Read the paper here

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The Sublaterodorsal Tegmental Nucleus Functions to Couple Brain State and Motor Activity during REM Sleep and Wakefulness

Authors: Zoltan A Torontali, Jimmy J Fraigne, Paul Sanghera, Richard Horner, and John Peever
Journal: Current Biology, 29: 1-11, 2019
​Read the paper here

Full List of Publications

• Before 2000s
• 2000 - 2010
• 2011 - 2016
• 2017 - 2022
• 2023 - Present

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​Tian GF, Peever JH, Duffin J (1999) Mutual inhibition between Botzinger-complex bulbospinal expiratory neurons detected with cross-correlation in the decerebrate rat. Exp Brain Res 125:440-446. Pubmed

Tian GF, Peever JH, Duffin J (1999) Botzinger-complex, bulbospinal expiratory neurones monosynaptically inhibit ventral-group respiratory neurones in the decerebrate rat. Exp Brain Res 124:173-180. Pubmed

Peever JH, Tian GF, Duffin J (1999) Temperature and pH affect respiratory rhythm of in-vitro preparations from neonatal rats. Respir Physiol 117:97-107. Pubmed

Tian GF, Peever JH, Duffin J (1998) Botzinger-complex expiratory neurons monosynaptically inhibit phrenic motoneurons in the decerebrate rat. Exp Brain Res 122:149-156. Pubmed

Tian GF, Peever JH, Duffin J (1998) Synaptic connections to phrenic motoneurons in the decerebrate rat. Adv Exp Med Biol 450:51-59. Pubmed

Peever JH, Tian GF, Duffin J (1998) Bilaterally independent respiratory rhythms in the decerebrate rat. Neurosci Lett 247:41-44. Pubmed

Peever JH, Stephenson R (1997) Day-night differences in the respiratory response to hypercapnia in awake adult rats. Respir Physiol 109:241-248. Pubmed

Tadjalli A, Peever J (2010) Sleep loss reduces respiratory motor plasticity. Adv Exp Med Biol 669:289-292. Pubmed

Tadjalli A, Peever J (2010) Role of neurotrophic signaling pathways in regulating respiratory motor plasticity. Adv Exp Med Biol 669:293-296. Pubmed

Tadjalli A, Duffin J, Peever J (2010) Repeated obstructive apneas induce long-term facilitation of genioglossus muscle tone. Adv Exp Med Biol 669:297-301. Pubmed

Tadjalli A, Duffin J, Peever J (2010) Identification of a novel form of noradrenergic-dependent respiratory motor plasticity triggered by vagal feedback. J Neurosci 30:16886-16895. Pubmed

Schwarz PB, Peever JH (2010) Noradrenergic control of trigeminal motoneurons in sleep: relevance to sleep apnea. Adv Exp Med Biol 669:281-284. Pubmed

Peever J (2010) The ins and outs of deep breathing: mechanisms of respiratory motor plasticity. J Appl Physiol (1985) 109:265-266. Pubmed

Burgess CR, Tse G, Gillis L, Peever JH (2010) Dopaminergic regulation of sleep and cataplexy in a murine model of narcolepsy. Sleep 33:1295-1304. Pubmed

Brooks PL, Peever JH (2010) GABAergic and glycinergic control of upper airway motoneurons in rapid eye movement sleep. Adv Exp Med Biol 669:259-262. Pubmed

Tadjalli A, Duffin J, Peever J (2008) Intermittent hypoxia induces respiratory long-term facilitation in postnatal rats. Adv Exp Med Biol 605:233-238. Pubmed

Schwarz PB, Yee N, Mir S, Peever JH (2008) Noradrenaline triggers muscle tone by amplifying glutamate-driven excitation of somatic motoneurones in anaesthetized rats. J Physiol 586:5787-5802. Pubmed

Lai YY, Hsieh KC, Nguyen D, Peever J, Siegel JM (2008) Neurotoxic lesions at the ventral mesopontine junction change sleep time and muscle activity during sleep: an animal model of motor disorders in sleep. Neuroscience 154:431-443. Pubmed

Burgess C, Lai D, Siegel J, Peever J (2008) An endogenous glutamatergic drive onto somatic motoneurons contributes to the stereotypical pattern of muscle tone across the sleep-wake cycle. J Neurosci 28:4649-4660. Pubmed

Brooks PL, Peever JH (2008) Biochemical control of airway motor neurons during rapid eye movement sleep. Adv Exp Med Biol 605:437-441. Pubmed

Brooks PL, Peever JH (2008) Unraveling the mechanisms of REM sleep atonia. Sleep 31:1492-1497. Pubmed

Brooks PL, Peever JH (2008) Glycinergic and GABA(A)-mediated inhibition of somatic motoneurons does not mediate rapid eye movement sleep motor atonia. J Neurosci 28:3535-3545. Pubmed

Tadjalli A, Duffin J, Li YM, Hong H, Peever J (2007) Inspiratory activation is not required for episodic hypoxia-induced respiratory long-term facilitation in postnatal rats. J Physiol 585:593-606. Pubmed

Peever JH, Lai YY, Siegel JM (2003) Excitatory effects of hypocretin-1 (orexin-A) in the trigeminal motor nucleus are reversed by NMDA antagonism. J Neurophysiol 89:2591-2600. Pubmed

Li YM, Shen L, Peever JH, Duffin J (2003) Connections between respiratory neurones in the neonatal rat transverse medullary slice studied with cross-correlation. J Physiol 549:327-332. Pubmed

Shen L, Peever JH, Duffin J (2002) Bilateral coordination of inspiratory neurones in the rat. Pflugers Arch 443:829-835. Pubmed

Peever JH, Shen L, Duffin J (2002) Respiratory pre-motor control of hypoglossal motoneurons in the rat. Neuroscience 110:711-722. Pubmed

Necakov A, Peever JH, Shen L, Duffin J (2002) Acetazolamide and respiratory chemosensitivity to CO(2) in the neonatal rat transverse medullary slice. Respir Physiol Neurobiol 132:279-287. Pubmed

Kiyashchenko LI, Mileykovskiy BY, Maidment N, Lam HA, Wu MF, John J, Peever J, Siegel JM (2002) Release of hypocretin (orexin) during waking and sleep states. J Neurosci 22:5282-5286. Pubmed

Peever JH, Necakov A, Duffin J (2001) Nucleus raphe obscurus modulates hypoglossal output of neonatal rat in vitro transverse brain stem slices. J Appl Physiol (1985) 90:269-279. Pubmed

Peever JH, Mateika JH, Duffin J (2001) Respiratory control of hypoglossal motoneurones in the rat. Pflugers Arch 442:78-86. Pubmed

Peever JH, Duffin J (2001) Bilateral synchronisation of respiratory motor output in rats: adult versus neonatal in vitro preparations. Pflugers Arch 442:943-951. Pubmed

Peever JH, Duffin J (2001) Respiratory control of hypoglossal motoneurons. Adv Exp Med Biol 499:101-106. Pubmed

Duffin J, Tian GF, Peever JH (2000) Functional synaptic connections among respiratory neurons. Respir Physiol 122:237-246. Pubmed

Brooks PL, Peever J (2016) A Temporally Controlled Inhibitory Drive Coordinates Twitch Movements during REM Sleep. Curr Biol 26(9): 1177-1182. Pubmed

Peever J, Fuller PM (2016) Neuroscience: A Distributed Neural Network Controls REM Sleep. Curr Biol 26:R34-35. Pubmed

Peever J, Horner RL (2015) Human Behavior: Sleep in Hunter-Gatherer Societies. Curr Biol 25:R1133-1135. Pubmed

​Lyamin OI, Lapierre JL, Kosenko PO, Kodama T, Bhagwandin A, Korneva SM, Peever JH, Mukhametov LM, Siegel JM (2015) Monoamine Release during Unihemispheric Sleep and Unihemispheric Waking in the Fur Seal. Sleep. Pubmed

Fraigne JJ, Torontali ZA, Snow MB, Peever JH (2015) REM Sleep at its Core - Circuits, Neurotransmitters, and Pathophysiology. Front Neurol 6:123. Pubmed

Xiong W, Chen SR, He L, Cheng K, Zhao YL, Chen H, Li DP, Homanics GE, Peever J, Rice KC, Wu LG, Pan HL, Zhang L (2014) Presynaptic glycine receptors as a potential therapeutic target for hyperekplexia disease. Nat Neurosci 17:232-239.​ Pubmed

Torontali ZA, Grace KP, Horner RL, Peever JH (2014) Cholinergic involvement in control of REM sleep paralysis. J Physiol 592:1425-1426. Pubmed

Peever J, Luppi PH, Montplaisir J (2014) Breakdown in REM sleep circuitry underlies REM sleep behavior disorder. Trends Neurosci 37:279-288. Pubmed

Kirshenbaum GS, Burgess CR, Dery N, Fahnestock M, Peever JH, Roder JC (2014) Attenuation of mania-like behavior in Na(+),K(+)-ATPase alpha3 mutant mice by prospective therapies for bipolar disorder: melatonin and exercise. Neuroscience 260:195-204. Pubmed

Schwarz PB, Mir S, Peever JH (2014) Noradrenergic modulation of masseter muscle activity during natural rapid eye movement sleep requires glutamatergic signalling at the trigeminal motor nucleus. J Physiol 592:3597-3609. Pubmed

Fraigne JJ, Grace KP, Horner RL, Peever J (2014) Mechanisms of REM sleep in health and disease. Curr Opin Pulm Med 20:527-532. Pubmed

Dauvilliers Y, Siegel JM, Lopez R, Torontali ZA, Peever JH (2014) Cataplexy--clinical aspects, pathophysiology and management strategy. Nat Rev Neurol 10:386-395. Pubmed

Lapierre JL, Kosenko PO, Kodama T, Peever JH, Mukhametov LM, Lyamin OI, Siegel JM (2013) Symmetrical serotonin release during asymmetrical slow-wave sleep: implications for the neurochemistry of sleep-waking states. J Neurosci 33:2555-2561. Pubmed

Fraigne JJ, Peever JH (2013) Melanin-concentrating hormone neurons promote and stabilize sleep. Sleep 36:1767-1768. Pubmed

Fraigne JJ, Peever JH (2013) Brain biology: jerked around by sleep. Curr Biol 23:R954-956. Pubmed

Burgess CR, Peever JH (2013) A noradrenergic mechanism functions to couple motor behavior with arousal state. Curr Biol 23:1719-1725. Pubmed

Burgess CR, Oishi Y, Mochizuki T, Peever JH, Scammell TE (2013) Amygdala lesions reduce cataplexy in orexin knock-out mice. J Neurosci 33:9734-9742. Pubmed

Fraigne J, Peever J (2012) Sleep biology: tuning in while tuned out. Curr Biol 22:R945-947. Pubmed

Brooks PL, Peever JH (2012) Identification of the transmitter and receptor mechanisms responsible for REM sleep paralysis. J Neurosci 32:9785-9795. Pubmed

Schwarz PB, Peever JH (2011) Dopamine triggers skeletal muscle tone by activating D1-like receptors on somatic motoneurons. J Neurophysiol 106:1299-1309. Pubmed

Peever J (2011) Control of motoneuron function and muscle tone during REM sleep, REM sleep behavior disorder and cataplexy/narcolepsy. Arch Ital Biol 149:454-466. Pubmed

Kirshenbaum GS, Clapcote SJ, Duffy S, Burgess CR, Petersen J, Jarowek KJ, Yucel YH, Cortez MA, Snead OC, 3rd, Vilsen B, Peever JH, Ralph MR, Roder JC (2011) Mania-like behavior induced by genetic dysfunction of the neuron-specific Na+,K+-ATPase alpha3 sodium pump. Proc Natl Acad Sci U S A 108:18144-18149. Pubmed

Brooks PL, Peever JH (2011) Impaired GABA and glycine transmission triggers cardinal features of rapid eye movement sleep behavior disorder in mice. J Neurosci 31:7111-7121. Pubmed
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Lee H, Peever J (2020) Neuroscience: An Arousal Circuit that Senses Danger in Sleep. Curr Biol 30(12):R708-R709. Pubmed

M Hamieh, J Fraigne, J Peever (2021) The effect of sodium oxybate on cataplexy in orexin knockout mice
Sleep 44, A2-A3. article

Pintwala SK, Peever J (2021) Brain Circuits Underlying Narcolepsy. The Neuroscientist 29(6):R751-R766. article

Taksokhan A, Fraigne J, Peever J (2021) Neuroscience: Glutamate neurons in the medial septum control wakefulness. Curr Biol 31(7):R340-R342. article

Bevan AM, Luke R, Fraigne JJ, Peever JH (2019) A mouse model of RBD: inducing synucleinopathy in GABA/glycine neurons in the ventral medulla. Sleep Medicine. 64:S35-S36. article

Lee H, Fraigne JJ, Peever J (2019) Role of sublaterodorsal tegmental nucleus gaba neurons in sleep-wake control. Sleep Medicine. 64: S216. article

Pintwala S, Fraigne JJ, Chalmers J, Belsham D, Peever JH (2019) Transplanting immortal orexin cells in narcolepsy. Sleep Medicine. 64: S302-S303. article

Torontali ZA, Fraigne JJ, Sanghera P, Horner R, Peever J (2019) The Sublaterodorsal Tegmental Nucleus Functions to Couple Brain State and Motor Activity during REM Sleep and Wakefulness. Curr Biol 29(22):3803-3813. article

Luke R, Bevan A, Fraigne JJ, Peever JH (2019) Alpha-synuclein pathology in the rem sleep circuit triggers rem sleep behavior disorder in mice. Sleep Medicine. 64:S233​. article

Luke R, Bevan A, Fraigne JJ, Peever JH (2019) Sleep is not associated with neurofilament light chain (NfL) in a population-based study of middle-aged and elderly. Sleep Medicine. 64(S1eS359): S233. article

Venner A, Todd WD, Fraigne JJ, Bowrey H, Eban-Rothschild A, Kaur S, et al. (2019) Newly identified sleep–wake and circadian circuits as potential therapeutic targets. Sleep 42(5):zsz023. article

Fraigne JJ, Torontali ZA, Thomasian DW Li, Peever JH (2017)  A dedicated brainstem circuit controls REM sleep. J of Sleep and Sleep Disorders Research. 40(suppl_1): A44-A44. article

​Horner RL, Peever JH (2017) Brain Circuitry Controlling Sleep and Wakefulness. Lifelong Learning in Neurology 23(4): 955-972. Pubmed

Horton GA, Fraigne JJ, Torontali ZA, Snow MB, Lapierre JL, Liu H, Montandon G, Peever JH, Horner RL (2017) Activation of the Hypoglossal to Tongue Musculature Motor Pathway by Remote Control. Scientific Reports 7: 45860. Pubmed 

McKenna D, Peever J (2017) Degeneration of Rapid Eye Movement Sleep Circuitry Underlies Rapid Eye Movement Sleep Behavior Disorder. Movement Disorders 32(5): 636-644. Pubmed

Pintwala S, Fraigne JJ, Peever J (2017) Activation of glutamate cell sin the subcoerleus nucleus triggers cataplexy-life attacks in wild-type mice. Sleep. 40:A53-A54. article

Pintwala S, Peever J (2017) Circuit Mechanisms of Sleepiness and Cataplexy in Narcolepsy. Curr Opin Neurobiol 44: 50-58. Pubmed

​Peever J, Fuller PM (2017) The Biology of REM Sleep. Curr Biol 27(22): R1237-R1248. article

Shiromani PJ, Peever JH (2017) New Neuroscience Tools That Are Identifying the Sleep-Wake Circuit. Sleep 40(4): zsx032. Pubmed

Snow MB, Fraigne JJ, Thibault-Messier G, Chuen VL, Thomasian A, Horner RL, Peever J (2017) GABA Cells in the Central Nucleus of the Amygdala Promote Cataplexy. J Neurosci 37(15): 4007-4022. Pubmed

Torontali Z, Fraigne J, Peever J. (2017) Cataplexy produces muscles paralysis by recruiting the REM sleep circuit. J of Sleep and Sleep Disorders Research. 40(suppl_1): A54-A54. article

​Dugan BJ, Fraigne JJ, Peever J. (2024). REM sleep: Out-dreaming fear. Current Biology. 34(10): pR510-R512. article

Dugan BJ, Dockery M. (2024) Sex-Dependent Synaptic Alterations in a Mouse Model of Alzheimer's Disease. Jour of Neurosci. 44 (36): e0961242024. article

Luke R, Fraigne JJ, Peever JH (2024) Sleep: How stress keeps you up at night. Current Biology 34(1):R23-R25. article ​

​Dugan BJ, Lee H, Peever J. (2023). Glutamate neurons in the pedunculopontine tegmental nucleus control arousal state and motor behavior in mice. Sleep. 46(4):zsac322. article

Luke R, Alymova I (2023) Unraveling the Mechanisms Underlying Disordered Sleep in Alzheimer’s Disease. J Neurosci 43:7899–7901. article
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Pintwala SK, Fraigne JJ, Belsham DD, Peever JH (2023) Immortal orexin cell transplants restore motor-arousal synchrony during cataplexy. Curr Biol 33(8):R1550-R1564.e5. article

Taksokhan A, Kim K. (2023) Lateral Preoptic Hypothalamus: A Window to Understanding Insomnia. J Neurosci.43(5):682-684. article